Spatial organization of lysosomal exocytosis relies on membrane tension gradients - Institut Curie Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2023

Spatial organization of lysosomal exocytosis relies on membrane tension gradients

Hugo Lachuer
Laurent Le
Bruno Goud
Kristine Schauer

Abstract

Significance We show a role of membrane tension in lysosomal exocytosis. This process supports the release of molecules and vesicles from intracellular compartments called late endosomes/lysosomes. Lysosomal exocytosis is key to the repair and growth of the plasma membrane, the remodeling of the cell microenvironment and cell communication. It has also fundamental importance for virus release, cancer cell invasion, and lysosomal storage disorders. Thus, lysosomal exocytosis is a function of broad interest but not well understood. We reveal that a gradient of membrane tension in cells, organized by cellular adhesions, plays in important role in defining how lysosomal exocytosis is organized.
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Dates and versions

hal-04308069 , version 1 (26-11-2023)

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Hugo Lachuer, Laurent Le, Sandrine Lévêque-Fort, Bruno Goud, Kristine Schauer. Spatial organization of lysosomal exocytosis relies on membrane tension gradients. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (8), pp.e2207425120. ⟨10.1073/pnas.2207425120⟩. ⟨hal-04308069⟩
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