Spatial organization of lysosomal exocytosis relies on membrane tension gradients
Résumé
Significance We show a role of membrane tension in lysosomal exocytosis. This process supports the release of molecules and vesicles from intracellular compartments called late endosomes/lysosomes. Lysosomal exocytosis is key to the repair and growth of the plasma membrane, the remodeling of the cell microenvironment and cell communication. It has also fundamental importance for virus release, cancer cell invasion, and lysosomal storage disorders. Thus, lysosomal exocytosis is a function of broad interest but not well understood. We reveal that a gradient of membrane tension in cells, organized by cellular adhesions, plays in important role in defining how lysosomal exocytosis is organized.
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