Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids - Département Recherches Subatomiques
Journal Articles International Journal of Nanomedicine Year : 2017

Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids

Abstract

In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants.

Domains

Biomaterials
Fichier principal
Vignette du fichier
IJN-116749-nano-engineered-implant-as-new-platform-for-regenerative-nan_011217.pdf (4.95 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-01483946 , version 1 (22-08-2024)

Identifiers

Cite

Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Sandy Eap, David Brasse, et al.. Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids. International Journal of Nanomedicine, 2017, 12, pp.447 - 457. ⟨10.2147/ijn.s116749⟩. ⟨hal-01483946⟩
128 View
9 Download

Altmetric

Share

More