Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study - Etude épidémiologique sur les petits âges gestationnels
Journal Articles Acta Paediatrica Year : 2023

Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study

Pascal Boileau
Laurence Caeymaex
  • Function : Author

Abstract

Aim: To describe the circumstances, causes and timing of death in extremely preterm infants. Methods: We included from the EPIPAGE-2 study infants born at 24–26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants: alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST). The main cause of death was classified as respiratory disease, necrotizing enterocolitis, infection, central nervous system (CNS) injury, other or unknown. Results: Among 768 infants admitted to NICU, 224 died among which 89 died without WWLST and 135 with WWLST. The main causes of death were respiratory disease (38%), CNS injury (30%) and infection (12%). Among the infants who died with WWLST, CNS injury was the main cause of death (47%), whereas respiratory disease (56%) and infection (20%) were the main causes in case of death without WWLST. Half (51%) of all deaths occurred within the first 7 days of life, and 35% occurred within 8 and 28 days. Conclusion: The death of extremely preterm infants in NICU is a complex phenomenon in which the circumstances and causes of death are intertwined.
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hal-04194845 , version 1 (27-09-2023)

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Pascal Boileau, Mathilde Letouzey, Andrei Scott Morgan, Elsa Lorthe, Monique Kaminski, et al.. Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study. Acta Paediatrica, 2023, 112 (10), pp.2066-2074. ⟨10.1111/apa.16894⟩. ⟨hal-04194845⟩
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