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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Computational systems biology PTPN22 gene African Continental Ancestry Group France Young Adult Epitopes HLA-DRB1 Environment Polymorphism Ankylosing Age Factors Algeria ASSOCIATION STUDY Algerian population Biologie des systèmes Computational modeling Binding Sites Systems biology Anti-Idiotypic Receptors Autoantibody Production Single Nucleotide Rheumatoid Arthritis Autoimmune thyroid diseases Animals ATP Binding Cassette Transporter Linkage Disequilibrium Analysis Autoimmune thyroid disease Logical modelling Metabolic reprogramming Annotation standards Human genomics Female Family Tunisia Alleles Haplotypes Aged Genetic Association Studies Family Health Male Genetic Adult Rheumatoid Factor Middle Aged Phenotype Antirheumatic Agents Reproducibility Shared Epitope Polyarthrite rhumatoïde POLYMORPHISM Databases Rheumatoid arthritis Age of Onset ABCB1 European Continental Ancestry Group Autoantibodies Case-Control Studies Genetic Predisposition to Disease Association study Protein Tyrosine Phosphatase Genotype Adolescent Antibodies Ankylosing spondylitis Génétique In silico simulations Biocuration Computational biology Arthritis Cohort Studies Rheumatoid Arthritis Patient Autoimmune Diseases Rheumatoid Anti-citrullinated protein antibodies Autoimmunity Non-Receptor Type 22 Complex genetic disease Network inference Genetics 80 and over APOPTOSIS HLA-DR Antigens Gene Frequency Risk Factors Hybrid modeling Transcriptome Rare variants Genetic Linkage RHEUMATOID ARTHRITIS Humans Biological pathway Biologie computationnelle des systèmes Odds Ratio Antigen Presentation Disease maps Antigens HLA-DRB1 Chains Europe

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