EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Autoimmune thyroid diseases PTPN22 gene Genotype Network inference Aged Humans Middle Aged Male Transcriptome Age Factors ASSOCIATION STUDY Autoimmune thyroid disease Rheumatoid Arthritis Patient Autoimmunity POLYMORPHISM Génétique Association study HLA-DR Antigens Binding Sites APOPTOSIS Polyarthrite rhumatoïde Rheumatoid Arthritis Age of Onset Antibiotic resistance Biocuration Antigens Adolescent Rare variants Phenotype Female Ankylosing spondylitis Family Health Receptors Antirheumatic Agents Single Nucleotide Genetic Anti-citrullinated protein antibodies Linkage Disequilibrium HLA-DRB1 Chains Algerian population Algeria Annotation standards Cohort Studies Autoimmune Diseases Rheumatoid In silico simulations European Continental Ancestry Group ATP Binding Cassette Transporter Computational systems biology Shared Epitope Arthritis Computational biology Rheumatoid arthritis Analysis Systems biology Ankylosing Human genomics HLA-DRB1 Computational modeling RHEUMATOID ARTHRITIS Databases Autoantibodies Family Environment Biological pathway Haplotypes Anti-Idiotypic Logical modelling Young Adult Tunisia Europe 80 and over ABCB1 Antibodies Protein Tyrosine Phosphatase Polymorphism Risk Factors Genetic Association Studies Alleles Autoantibody Production Biologie computationnelle des systèmes France Gene Frequency Non-Receptor Type 22 Adult Genetic Linkage Antigen Presentation Complex genetic disease Odds Ratio Epitopes African Continental Ancestry Group Animals Rheumatoid Factor Metabolic reprogramming Genetic Predisposition to Disease Genetics Disease maps Reproducibility Hybrid modeling Case-Control Studies

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