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Theses

Quantitative study of structural variations of chromosomes in saccharomyces cerevisiae

Abstract : The accumulation of chromosomal rearrangements also called Structural Variations (SV) is a major contributor to the transformation of tumoral cells and to the constitution of intratumoral heterogeneity. We have developed a bio-informatic tool that can now provide a sharp image of SV that occur in the human genome. We have demonstrated the existence of SV present in low proportions in different supposedly clonal cell populations showing that the rates of SV formation could be greatly underestimated. In parallel, we have shown that the level of instability of the genome depends on predisposition factors. To identify those, we have developed genetic assays to measure the rate of SV in yeast that will allow us to identify new genes controlling the stability of the genome using large scale linkage analysis. These regulators represent new gene-candidates involved in the development of cancer in human as the determinants involved in DNA metabolism are very conserved between yeast and mammals.
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https://tel.archives-ouvertes.fr/tel-01261378
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Submitted on : Monday, January 25, 2016 - 11:30:06 AM
Last modification on : Thursday, December 10, 2020 - 11:04:46 AM
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2015PA066233.pdf
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  • HAL Id : tel-01261378, version 1

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Alexandre Gillet-Markowska. Quantitative study of structural variations of chromosomes in saccharomyces cerevisiae. Genetics. Université Pierre et Marie Curie - Paris VI, 2015. English. ⟨NNT : 2015PA066233⟩. ⟨tel-01261378⟩

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