Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT)

Gael S. Roth; Loic Verlingue; Matthieu Sarabi; Jean Frédéric Blanc; Emmanuel Boleslawski; Karim Boudjema; Anne Laure Bretagne-Bignon; Marine Camus-Duboc; Romain Coriat; Gilles Créhange; Thierry de Baere; Christelle de la Fouchardière; Clarisse Dromain; Julien Edeline; Maximiliano Gelli; Boris Guiu; Samy Horn; Valérie Laurent-Croise; Côme Lepage; Astrid Lièvre; Anthony Lopez; Sylvain Manfredi; Julie Meilleroux; Cindy Neuzillet; Valérie Paradis; Frédéric Prat; Maxime Ronot; Olivier Rosmorduc; Antonio Sa Cunha; Olivier Soubrane; Anthony Turpin; Christophe Louvet; Olivier Bouché; David Malka

doi:10.1016/j.ejca.2024.114000

Journal Articles European Journal of Cancer Year : 2024

Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT)

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Gael S. Roth

Function : Author

Université Grenoble Alpes

Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)

Centre Hospitalier Universitaire [CHU Grenoble]

Loic Verlingue

Function : Author
PersonId : 1362943
ORCID : 0000-0002-5694-4022

Centre Léon Bérard [Lyon]

Matthieu Sarabi

Function : Author
PersonId : 1258947
ORCID : 0000-0003-4588-0585

Hôpital privé Jean Mermoz [Lyon]

Jean Frédéric Blanc

Function : Author

Centre Hospitalier Universitaire de Bordeaux

Emmanuel Boleslawski

Function : Author
PersonId : 825726
ORCID : 0000-0003-3286-8608
IdRef : 072240253

Université de Lille

Centre Hospitalier Régional Universitaire [CHU Lille]

Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189

Karim Boudjema

Function : Author

Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]

Anne Laure Bretagne-Bignon

Function : Author

CHU Caen

Marine Camus-Duboc

Function : Author

Sorbonne Université

CHU Saint-Antoine [AP-HP]

Romain Coriat

Function : Author
PersonId : 1180377
ORCID : 0000-0003-4420-8340

AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris]

Gilles Créhange

Function : Author

Institut Curie [Paris]

Université Paris Sciences et Lettres

Thierry de Baere

Function : Author

Institut Gustave Roussy

Christelle de la Fouchardière

Function : Author

Institut Paoli-Calmettes

Clarisse Dromain

Function : Author

Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]

Julien Edeline

Function : Author

CRLCC Eugène Marquis

Maximiliano Gelli

Function : Author

Institut Gustave Roussy

Boris Guiu

Function : Author

Université de Montpellier

Hôpital Saint Eloi

Samy Horn

Function : Author

Centre Hospitalier Lyon Sud [CHU - HCL]

Valérie Laurent-Croise

Function : Author

Centre Hospitalier Régional Universitaire de Nancy

Côme Lepage

Function : Author

CHU Dijon

Lipides - Nutrition - Cancer [Dijon - U1231]

Astrid Lièvre

Function : Author

Oncogenesis, Stress, Signaling

Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]

Anthony Lopez

Function : Author

Nutrition-Génétique et Exposition aux Risques Environnementaux

Centre Hospitalier Régional Universitaire de Nancy

Sylvain Manfredi

Function : Author

Lipides - Nutrition - Cancer (U866)

CHU Dijon

Julie Meilleroux

Function : Author

Institut Universitaire du Cancer de Toulouse - Oncopole

Centre Hospitalier Universitaire de Toulouse

Cindy Neuzillet

Function : Author
PersonId : 758432
ORCID : 0000-0001-7037-7477
IdRef : 175820139

Institut Curie [Paris]

Université Paris-Saclay

Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil

Valérie Paradis

Function : Author

Université Paris Cité

Centre de recherche sur l'Inflammation

Hôpital Beaujon [AP-HP]

Frédéric Prat

Function : Author

Hôpital Beaujon [AP-HP]

Maxime Ronot

Function : Author
PersonId : 1167351
ORCID : 0000-0001-7464-3939

Hôpital Beaujon [AP-HP]

Olivier Rosmorduc

Function : Author

Université Paris-Saclay

Mécanismes cellulaires et moléculaires de l'adaptation au stress et cancérogenèse

Centre Hépato-Biliaire [Hôpital Paul Brousse]

Antonio Sa Cunha

Function : Author

Université Paris-Saclay

Mécanismes cellulaires et moléculaires de l'adaptation au stress et cancérogenèse

Centre Hépato-Biliaire [Hôpital Paul Brousse]

Olivier Soubrane

Function : Author

Institut Mutualiste de Montsouris

Anthony Turpin

Function : Author
PersonId : 802519
ORCID : 0000-0002-2282-0101

Université de Lille

Centre Hospitalier Régional Universitaire [CHU Lille]

Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277

Christophe Louvet

Function : Author
PersonId : 1395949
ORCID : 0000-0002-2240-4706

Institut Mutualiste de Montsouris

Olivier Bouché

Function : Author
PersonId : 1042426
ORCID : 0000-0002-8284-3743

AP-HP Hôpital universitaire Robert-Debré [Paris]

David Malka

Function : Correspondent author
PersonId : 1220544

Connectez-vous pour contacter l'auteur

Institut Mutualiste de Montsouris

Abstract

Introduction: This document is a summary of the French intergroup guidelines of the management of biliary tract cancers (BTC) (intrahepatic, perihilar and distal cholangiocarcinomas, and gallbladder carcinomas) published in September 2023, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org). Methods: This collaborative work was conducted under the auspices of French medical and surgical societies involved in the management of BTC. Recommendations were graded in three categories (A, B and C) according to the level of scientific evidence until August 2023. Results: BTC diagnosis and staging is mainly based on enhanced computed tomography, magnetic resonance imaging and (endoscopic) ultrasound-guided biopsy. Treatment strategy depends on BTC subtype and disease stage. Surgery followed by adjuvant capecitabine is recommended for localised disease. No neoadjuvant treatment is validated to date. Cisplatin-gemcitabine chemotherapy combined to the anti-PD-L1 inhibitor durvalumab is the first-line standard of care for advanced disease. Early systematic tumour molecular profiling is recommended to screen for actionable alterations (IDH1 mutations, FGFR2 rearrangements, HER2 amplification, BRAFV600E mutation, MSI/dMMR status, etc.) and guide subsequent lines of treatment. In the absence of actionable alterations, FOLFOX chemotherapy is the only second-line standard-of-care. No third-line chemotherapy standard is validated to date. Conclusion: These guidelines are intended to provide a personalised therapeutic strategy for daily clinical practice. Each individual BTC case should be discussed by a multidisciplinary team.

Keywords

Biliary tract cancer Chemotherapy Cholangiocarcinoma Clinical practice guidelines Gallbladder carcinoma Immunotherapy Surgery Targeted therapy

Domains

Cancer

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0	―	0	―	2
Year		Month		Jours

Avant la publication
Friday, September 13, 2024

Embargoed file

0	―	0	―	2
Year		Month		Jours

Avant la publication
Friday, September 13, 2024

Laurent Jonchère : Connect in order to contact the contributor

https://hal.science/hal-04626861

Submitted on : Thursday, July 11, 2024-3:21:55 PM

Last modification on : Monday, September 2, 2024-11:36:16 AM

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hal-04626861 , version 1 (11-07-2024)

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Attribution - NonCommercial

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HAL Id : hal-04626861 , version 1
DOI : 10.1016/j.ejca.2024.114000
PUBMED : 38493667

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Gael S. Roth, Loic Verlingue, Matthieu Sarabi, Jean Frédéric Blanc, Emmanuel Boleslawski, et al.. Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT). European Journal of Cancer, 2024, 202, pp.114000. ⟨10.1016/j.ejca.2024.114000⟩. ⟨hal-04626861⟩

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Biliary tract cancers: French national clinical practice guidelines for diagnosis, treatments and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, AFEF, SFRO, SFP, SFR, ACABi, ACHBPT)

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