Heart Thérapie génique Aging Centronuclear myopathy CTG repeats CMS Glucocorticoid-receptor PCR Exercise RNA splicing Astrocyte Knockout PacBio CTG repeat instability Cytoskeleton Myostatin Cardiac muscle Humans Fibrosis Motoneuron Myelin RNA interference Oligodendrocytes Trinucleotide repeat expansion Heart failure Neuron Gene Therapy Transgenic mouse model Hypoxia Brain Antisense oligonucleotide Antisense oligonucleotides Muscular dystrophy Intermediate filament Animals GSK3␤ Glutamate RNA biology Glial cells Therapy Male Endurance training AAV Exercice Expression DMPK KNOCKOUT MICE Myotonic Dystrophy Autophagy Long read sequencing Myotonic dystrophy mouse models CRISPR/Cas9 Muscle Cell culture model Dynamin 2 Central nervous system Dilated cardiomyopathy Duchenne muscular dystrophy Quantitative microdialysis GABA Acute coronary syndrome Dystrophin Myotonic dystrophy CTG repeat contractions Gene editing DMSXL mice Myotonic dystrophy type 1 Acetylcholinesterase deficiency Acetylcholinesterase knockout mouse Skeletal muscle Myotonic Dystrophy type 1 Dystrophie Myotonique In vivo CONGENITAL MYATHENIC SYNDROME Dystrophie myotonique Oligodendrocyte CRISPRi BIOLOGIE MOLECULAIRE Gene therapy Genotype phenotype correlation DM1 MBNL Mouse models ACETYLCHOLINESTERASE Myotonic Dystrophy Type 1 Desmin Cell model Diaphragm Brain dysfunction Glucocorticoids Transgenic mouse Trinucleotide Repeat Expansion ARN Alternative splicing Mice Transcriptomics Maximal force Cell penetrating peptide Mouse model Astrocytes