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Journal Articles Lab on a Chip Year : 2022

Frontiers in single cell analysis: multimodal technologies and their clinical perspectives

Julia Källberg
Wenjin Xiao
  • Function : Author
David van Assche
  • Function : Author
Jean-Christophe Baret
Valerie Taly

Abstract

Single cell multimodal analysis is at the frontier of single cell research: it defines the roles and functions of distinct cell types through simultaneous analysis to provide unprecedented insight into cellular processes. Current single cell approaches are rapidly moving toward multimodal characterizations. It replaces onedimensional single cell analysis, for example by allowing for simultaneous measurement of transcription and post-transcriptional regulation, epigenetic modifications and/or surface protein expression. By providing deeper insights into single cell processes, multimodal single cell analyses paves the way to new understandings in various cellular processes such as cell fate decisions, physiological heterogeneity or genotype-phenotype linkages. At the forefront of this, microfluidics is key for high-throughput single cell analysis. Here, we present an overview of the recent multimodal microfluidic platforms having a potential in biomedical research, with a specific focus on their potential clinical applications.
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Dates and versions

hal-04301278 , version 1 (22-11-2023)

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Julia Källberg, Wenjin Xiao, David van Assche, Jean-Christophe Baret, Valerie Taly. Frontiers in single cell analysis: multimodal technologies and their clinical perspectives. Lab on a Chip, 2022, 22, pp.2403 - 2422. ⟨10.1039/d2lc00220e⟩. ⟨hal-04301278⟩
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