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Journal Articles iScience Year : 2022

Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patients

Mehran Monchi
  • Function : Author
Thomas Bruneau
  • Function : Author
Sebastien Jochmans
  • Function : Author
David Veyer
  • Function : Author
Aurelia Pitsch
  • Function : Author
Olivier Ellrodt
  • Function : Author
Marie Picque
  • Function : Author
Valérie Taly
Oumar Sy
  • Function : Author
Sandie Mazerand
  • Function : Author
Sylvain Diamantis
  • Function : Author

Abstract

It has been suggested that during the period of respiratory worsening of severe COVID-19 patients, viral replication plays a less important role than inflammation. Using the droplet-based digital PCR (ddPCR) for precise quantification of plasma SARS-CoV-2 viral load (SARS-CoV-2 RNAemia), we investigated the relationship between plasma viral load, comorbidities, and mortality of 122 critically ill COVID-19 patients. SARS-CoV-2 RNAemia was detected by ddPCR in 90 (74%) patients, ranging from 70 to 213,152 copies per mL. A high (>1 000 copies/ml) or very high (>10,000 copies/ml) SARS-Cov-2 RNAemia was observed in 46 patients (38%), of which 26 were diabetic. Diabetes was independently associated with a higher SARS-CoV-2 RNAemia. In multivariable logistic regression models, SARS-CoV-2 RNAemia was strongly and independently associated with day-60 mortality. Early initiation of antiviral therapies might be considered in COVID-19 critically ill patients with high RNAemia.
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Dates and versions

hal-04301320 , version 1 (22-11-2023)

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Mehran Monchi, Thomas Bruneau, Sebastien Jochmans, David Veyer, Aurelia Pitsch, et al.. Association of high SARS-CoV-2 RNAemia with diabetes and mortality in critically ill COVID-19 patients. iScience, 2022, ⟨10.1016/j.isci⟩. ⟨hal-04301320⟩
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