The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
Lucia Sideli
(1, 2, 3)
,
Monica Aas
(4, 2, 5, 6, 7)
,
Diego Quattrone
(8)
,
Daniele La Barbera
(1)
,
Caterina La Cascia
(1)
,
Laura Ferraro
(1)
,
Luis Alameda
(2, 9, 10, 11, 12, 13)
,
Eva Velthorst
(14)
,
Giulia Trotta
(2)
,
Giada Tripoli
(1, 2)
,
Adriano Schimmenti
(15)
,
Andrea Fontana
(3)
,
Charlotte Gayer-Anderson
(2, 16)
,
Simona Stilo
(2, 16)
,
Fabio Seminerio
(1)
,
Crocettarachele Sartorio
(1)
,
Giovanna Marrazzo
(1)
,
Antonio Lasalvia
(17)
,
Sarah Tosato
(17)
,
Ilaria Tarricone
(18)
,
Domenico Berardi
(18)
,
Giuseppe D’andrea
(18)
,
Celso Arango
(19, 20, 9)
,
Manuel Arrojo
(21, 22)
,
Miguel Bernardo
(23, 24, 9, 25)
,
Julio Bobes
(26, 9, 27)
,
Julio Sanjuán
(28, 9)
,
Jose Luis Santos
(29)
,
Paulo Rossi Menezes
(30)
,
Cristina Marta Del-Ben
(30)
,
Hannah E Jongsma
(31, 32)
,
Peter B Jones
(33, 34)
,
James B Kirkbride
(31)
,
Pierre-Michel Llorca
(34)
,
Andrea Tortelli
(35)
,
Baptiste Pignon
(36, 37, 38)
,
Lieuwe de Haan
(39)
,
Jean-Paul Selten
(40, 14)
,
Jim van Os
(2, 40, 41)
,
Bart P Rutten
(40)
,
Richard Bentall
(42)
,
Marta Di Forti
(2, 16)
,
Robin M Murray
(2, 16)
,
Craig Morgan
(2, 16)
,
Helen L Fisher
(2, 16)
1
Università degli studi di Palermo - University of Palermo
2 King‘s College London
3 LUMSA - LUMSA University - Libera Università Maria SS. Assunta [Rome, Italy]
4 UiO - University of Oslo
5 Oslo University Hospital [Oslo]
6 OsloMet - Oslo Metropolitan University
7 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
8 Institute of Psychiatry, Psychology & Neuroscience, King's College London
9 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
10 Hospital Universitario Virgen del Rocío [Sevilla]
11 Universidad de Sevilla = University of Seville
12 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
13 IBIS/HUVR - Instituto de Biomedicina de Sevilla [Sevilla, Spain]
14 GGZ NHN - Mental Health Service Organization - GGZ Noord-Holland-Noord [Hoorn, Netherlands]
15 Università degli Studi di Enna " KORE " = Kore University of Enna
16 Institute of Psychiatry, Psychology, and Neuroscience
17 UNIVR - Università degli studi di Verona = University of Verona
18 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
19 Hospital General Universitario "Gregorio Marañón" [Madrid]
20 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
21 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
22 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
23 UB - Universitat de Barcelona
24 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
25 ISC - Instituto de Salud Carlos III [Madrid]
26 Universidad de Oviedo [Oviedo]
27 ISPA - Institute for Health Research of the Principality of Asturias [Oviedo,Spain]
28 UV - Universitat de València
29 HVDL - Hospital Virgen de La Luz [Cuenca, Spain]
30 USP - Universidade de São Paulo = University of São Paulo
31 UCL - University College of London [London]
32 CAM - University of Cambridge [UK]
33 CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge]
34 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
35 Hôpital Maison Blanche
36 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
37 Hôpital Henri Mondor
38 Fondation FondaMental [Créteil]
39 Amsterdam UMC - Amsterdam University Medical Center
40 MUMC - Maastricht University Medical Centre
41 University Medical Center [Utrecht]
42 University of Sheffield [Sheffield]
2 King‘s College London
3 LUMSA - LUMSA University - Libera Università Maria SS. Assunta [Rome, Italy]
4 UiO - University of Oslo
5 Oslo University Hospital [Oslo]
6 OsloMet - Oslo Metropolitan University
7 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
8 Institute of Psychiatry, Psychology & Neuroscience, King's College London
9 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
10 Hospital Universitario Virgen del Rocío [Sevilla]
11 Universidad de Sevilla = University of Seville
12 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
13 IBIS/HUVR - Instituto de Biomedicina de Sevilla [Sevilla, Spain]
14 GGZ NHN - Mental Health Service Organization - GGZ Noord-Holland-Noord [Hoorn, Netherlands]
15 Università degli Studi di Enna " KORE " = Kore University of Enna
16 Institute of Psychiatry, Psychology, and Neuroscience
17 UNIVR - Università degli studi di Verona = University of Verona
18 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
19 Hospital General Universitario "Gregorio Marañón" [Madrid]
20 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
21 IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela / Health Research Institute of Santiago de Compostela
22 CHUS - Complejo Hospitalario Universitario de Santiago de Compostela [Saint-Jacques-de-Compostelle, Espagne]
23 UB - Universitat de Barcelona
24 IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
25 ISC - Instituto de Salud Carlos III [Madrid]
26 Universidad de Oviedo [Oviedo]
27 ISPA - Institute for Health Research of the Principality of Asturias [Oviedo,Spain]
28 UV - Universitat de València
29 HVDL - Hospital Virgen de La Luz [Cuenca, Spain]
30 USP - Universidade de São Paulo = University of São Paulo
31 UCL - University College of London [London]
32 CAM - University of Cambridge [UK]
33 CPFT - Cambridgeshire & Peterborough NHS Foundation Trust [Cambridge]
34 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
35 Hôpital Maison Blanche
36 U955 Inserm - UPEC - IMRB - "Neuropsychiatrie translationnelle" [Créteil]
37 Hôpital Henri Mondor
38 Fondation FondaMental [Créteil]
39 Amsterdam UMC - Amsterdam University Medical Center
40 MUMC - Maastricht University Medical Centre
41 University Medical Center [Utrecht]
42 University of Sheffield [Sheffield]
Résumé
This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Origine : Publication financée par une institution
licence : CC BY - Paternité
licence : CC BY - Paternité